Nootropics for diabetes? Noopept might work.

Noopept’s co-creator Dr. Rita Ostrovskaya says it’s likely that it and other nootropics can help battle diabetes.

This is another “notes” post, from Smart Drug Smarts podcast.

This time: a short history and primer on noopept

Let’s get into it.

A Brief History

It was invented out of a desire to improve on Piracetam because…

Dr. Rita says Piracetam has a few disadvantages:

[1] Works only in very high doses. She said 12g/day (!)

If you read my post on the racetam nootropics, you know I hit on the sweet spot for piracetam dosing which was 4.8 grams/day taken in three, 1.6g doses.

[2] In some people, it’s ineffective

At the time, there were a lot of attempts to make piracetam better because of the aformentioned downsides. Her institute decided to switch gears and focus on peptides that have nootropic function.

Peptides pros are that they are fairly safe. The downside is that they can be biologically unstable once ingested due to enzymes slicing and dicing them. This is especially true for longer peptides.

Dipeptides (2 amino acids bonded together) have different properties though. They are more stable and cross the blood brain barrier easier.

They started by looking at the structure of Piracetam and to see which peptides/amino acids could they “lego block” together to mimic that structure.

It turns out that proline and glycine mock Piracetam’s structure very well, and Noopept was born from those 2 amino acids.

Glycine

Glycine is fascinating as hell, btw. Get you some.

So well that Noopept has about a 1000x more effective dose level than Piracetam1.

She says:

“Piracetam works in 200mg/kg and our substance works in 1mg/kg”

When she and her colleagues did tests on rats and rabbits, they found very low toxicity. Probably because Noopept is treated like peptides in the body.

Other interesting points

Jesse asked her if there are any downsides to be worried about? “Not yet […]” she answered, “There is really no side effects except one. […]”

People with hypertonia had a bit higher blood pressure after taking it. She thought maybe it was psychological due to the nature of pharmacology clinical trials when done on humans. My blood pressure might be higher too if I was a lab rat, pioneering “I wonder what side effects will this have on humans.”

Jesse mentioned that Noopept might have anti-diabetic effects1,2

She said that she has some experimental data that shows it is working to fight diabetes (no human trials because she has to get permission and it’s very expensive). Other substances show some promise also.

How crazy is that? Nootropics for diabetes.

But you might be thinking, “So…are the dosages for the nootropics effects similar for the effective dose for fighting diabetes?” She says it’s very early data and no one knows.

Dr. Rita quotes Dr. Suzanne DeLaMonte who says Alzheimer’s may be the “diabetes of the brain.”

If so, can noopept help? Hopefully further researches is done.

She also said something that’s very interesting to me: any kind of brain damage, no matter the origin seems to have the same common mechanisms as a foundation:

  1. “excessive formation of free oxygen” [reactive oxygen species / free radicals]
  2. Increased/excessive glutamic acid (a neurotransmitter that’s an excitatory amino acid)
  3. “Excessive accumulation of pro-inflammatory cytokines”

Why am I interested in that?

[1] Diet can help control all 3 of those to some extent (I’ve been spending a lot of time studying metabolism and how to make diet and exercise act as powerful nootropics)
[2] Noopept and piracetam mechanisms seem to oppose those 3 metabolic damages mentioned above

Over and out,
Nootroponaut

P.S.
Want to stack the odds in your favor and potentially fight off “diabeetus?”

Wilford Brimley Diabeetus

Buy cheap and high-quality noopept at Nootropics Depot:

Powder

Capsules

5 grams of powder for $7.99 | 30mg/day will last ~166 days.

Takeaways

  1. If you want to protect your brain, use diet and supplement with noopept.
  2. Dr. Rita says it has no tolerance, but she recommends you take it for no more than 3 months before cycling off. She recommends cycling off 3 times per year.
  3. Up to 30mg/day can be taken.
  4. It’s metabolized very quickly, as all nearly all peptides.
  5. She’s 82 and has been taking noopept for years.
  6. Adenosine build up in the brain causes us to get tired and sleepy